The children’s brain tumor network (CBTN)-Accelerating research in pediatric central nervous system tumors through collaboration and open science

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Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents,Êand collected over 65,000ÊÉ

Recommended citation: Lilly, J., Rokita, J. L., Mason, J., Patton, T. S., Stefankiewiz, S., Higgins, D., Trooskin, G., Larouci, C. A., Arya, K., Appert, E., Heath, A., Zhu, Y., Brown, M., Zhang, B., Farrow, B., Robins, S., Morgan, A. J., Nguyen, T. Q., Frenkel, E., . . . Waanders, A. J. (2023). The childrenÕs brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science. Neoplasia, 35, 100846. https://doi.org/10.1016/j.neo.2022.100846